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Interleukin-5 is at 5q31 and is deleted in the 5q- syndrome

GR Sutherland, E Baker, DF Callen, HD Campbell, IG Young, CJ Sanderson, OM Garson, AF Lopez and MA Vadas

Cytogenetics Unit, Adelaide Children's Hospital, Australia.

Human interleukin-5 (IL-5) is a selective eosinophilopoietic and eosinophil-activating growth hormone. By in situ hybridization this gene is mapped to chromosome 5q23.3 to 5q32. It is shown to be deleted in two patients with the 5q-syndrome and in one patient previously diagnosed with myelodysplasia whose condition had progressed to acute myeloblastic leukemia. The clustering of other genes involved in hematopoiesis (IL-3, granulocyte-macrophage colony-stimulating factor, feline sarcoma viral oncogene homolog, colony-stimulating factor 1) to the same region as IL-5 suggests a nonrandom localization and raises interesting questions concerning the evolution and regulation of these genes.

Volume 71, Issue 4, pp. 1150-1152, 04/01/1988
Copyright © 1988 by The American Society of Hematology


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