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Low doses v conventional doses of corticoids in immune thrombocytopenic
purpura (ITP): results of a randomized clinical trial in 160 children, 223
adults
S Bellucci, Y Charpak, C Chastang and G Tobelem
Department d'Hematologie, Hopital Lariboisiere, France.
A randomized clinical trial was performed in 160 children and 223 adults
with acute immune thrombocytopenic purpura (ITP). The role of corticoids at
this phase of the disease is still controversial. Therefore, patients were
randomized to receive either conventional doses (1 mg/kg/day) of
corticotherapy or low doses (0.25 mg/kg/day) for 3 weeks. The remission,
defined by platelet count superior to 100,000/microliter was studied for
adults and children after 6 months and 12 months, respectively. The
statistical analysis showed no significant difference between the two
corticotherapy regimens neither in children nor in adults. Overall, 74% of
children and 41% of adults were in remission. For the first time in acute
ITP, a randomized prospective trial showed that both in children and adults
low dose corticotherapy (0.25 mg/kg/day) proves to have the same efficacy
as conventional doses (1 mg/kg/day).
Volume 71,
Issue 4,
pp. 1165-1169,
04/01/1988
Copyright © 1988 by The American Society of Hematology
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