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Phenotypic heterogeneity in aneuploid multiple myeloma indicates pre-B cell involvement

J Epstein, B Barlogie, J Katzmann and R Alexanian

Department of Hematology, University of Texas System Cancer Center, Houston 77030.

The expression of early and mature B cell markers, surface beta 2- microglobulin (B2M) and cytoplasmic immunoglobulin (clg) by aneuploid tumor cells in bone marrow aspirates from 44 patients with multiple myeloma was evaluated by correlated DNA immunofluorescence flow cytometry. Myeloma tumor cells of almost 90% of the patients contained monoclonal clg and expressed the mature plasma cell antigen R1-3 as well as surface B2M; common acute lymphoblastic leukemia antigen (CALLA) was present in 55%, B2 in 17%, and B4 in 23% of samples studied. Coexpression of CALLA and clg in 46% of all patients identified a novel myeloma phenotype without known counterpart in the normal differentiation of B cells. CALLA and clg were independently expressed and gave rise to CALLA+/clg-, CALLA+/clg+, and CALLA-/clg+ cells. The association of CALLA and mature plasma cell markers may define discrete stages of neoplastic plasma cell differentiation.

Volume 71, Issue 4, pp. 861-865, 04/01/1988
Copyright © 1988 by The American Society of Hematology


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S. Yaccoby and J. Epstein
The Proliferative Potential of Myeloma Plasma Cells Manifest in the SCID-hu Host
Blood, November 15, 1999; 94(10): 3576 - 3582.
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