Identification of Bakb, a new platelet-specific antigen associated with
posttransfusion purpura
TS Kickler, JH Herman, K Furihata, TJ Kunicki and RH Aster
Johns Hopkins University School of Medicine, Baltimore, MD.
Baka is a platelet alloantigen whose putative allele, Bakb, has not been
identified previously. By using a serum, "Har," obtained from a patient
with posttransfusion purpura, we describe the platelet alloantigen Bakb.
The Har serum reacted with an NP-40-extractable platelet membrane protein
of 142 kd with mobility similar to platelet glycoprotein IIb alpha. We
found that the antigen recognized by the Har serum is inherited in an
autosomal dominant mode with an apparent gene frequency of .39. Chi-square
analysis of observed and expected phenotype frequencies indicated that
serum Har recognizes Bakb, the anticipated allele of Baka. Our findings
provide new evidence for polymorphism of glycoprotein IIb and for the
association of posttransfusion purpura with alloimmunization to
determinants on this glycoprotein.
Volume 71,
Issue 4,
pp. 894-898,
04/01/1988
Copyright © 1988 by The American Society of Hematology
