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Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow

KM Zsebo, J Wypych, VN Yuschenkoff, H Lu, P Hunt, PP Dukes and KE Langley

Amgen, Thousand Oaks, CA 91320.

Hematopoietin-1 (H-1) was purified from the human cell line 5637 and two amino acid sequences were observed in the preparation. One sequence was identical to that of interleukin 1 alpha (IL 1 alpha) and the other to that of IL 1 beta. The action of recombinant IL 1 alpha and other hematopoietic growth factors was studied using (a) a high proliferative potential colony-forming cell assay that uses primitive hematopoietic precursors from bone marrow, and (b) a spleen colony-forming unit assay. The results indicate that the IL 1 alpha target cell population is different than the target cell populations of IL 3, granulocyte- macrophage colony-stimulating factor; that IL 1 alpha in combination with mononuclear phagocyte colony-stimulating factor provides a proliferative stimulus; and that IL 1 alpha has at least a survival- enhancing and possibly proliferation-inducing effect on primitive hematopoietic stem cells.

Volume 71, Issue 4, pp. 962-968, 04/01/1988
Copyright © 1988 by The American Society of Hematology


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