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Molecular cloning of the cDNA for human erythrocyte beta-spectrin

JC Winkelmann, TL Leto, PC Watkins, R Eddy, TB Shows, AJ Linnenbach, KE Sahr, N Kathuria, VT Marchesi and BG Forget

Department of Medicine, Yale University School of Medicine, New Haven, CT.

Overlapping cDNA clones, totaling 3.3 kilobases (kb) in length, which encode over 50% of the human erythrocyte beta-spectrin subunit, were isolated by antibody screening of a lambda gt11 expression library constructed from human fetal liver mRNA. The amino acid sequence of the C-terminus of beta-spectrin was derived. The size of beta-spectrin mRNA in human erythroleukemia cells was found to be 7.5 kb. Erythrocyte beta- spectrin is encoded by a gene located on human chromosome 14, as determined by cDNA hybridization to human X mouse somatic cell hybrids.

Volume 72, Issue 1, pp. 328-334, 07/01/1988
Copyright © 1988 by The American Society of Hematology


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