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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Huang, M. E. Articles by Wang, Z. Y. Search for Related Content PubMed PubMed Citation Articles by Huang, M. E. Articles by Wang, Z. Y. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia ME Huang, YC Ye, SR Chen, JR Chai, JX Lu, L Zhoa, LJ Gu and ZY Wang Shanghai Institute of Hematology, Shanghai Second Medical University, People's Republic of China. Twenty-four patients with acute promyelocytic leukemia (APL) were treated with all-trans retinoic acid (45 to 100 mg/m2/day). Of these, eight cases had been either nonresponsive or resistant to previous chemotherapy; the other 16 cases were previously untreated. All patients attained complete remission without developing bone marrow hypoplasia. Bone marrow suspension cultures were studied in 15 of the 24 patients. Fourteen of these patients had morphological maturation in response to the retinoic acid (1 mumol/L). Chloroacetate esterase and alpha-naphthyl acetate esterase staining as well as electronmicroscopic examination confirmed that retinoic acid-induced cells differentiated to granulocytes with increased functional maturation (as measured by nitroblue tetrazolium reduction, NBT). The single nonresponder to retinoic acid in vitro was resistant to treatment with retinoic acid but attained complete remission after addition of low-dose cytosine arabinoside (ara-C). During the course of therapy, none of the patients showed any abnormalities in the coagulation parameters we measured, suggesting an absence of any subclinical disseminated intravascular coagulation. The only side effects consisted of mild dryness of the lips and skin, with occasional headaches and digestive symptoms. Eight patients have relapsed after 2 to 5 months of complete remission. The others remain in complete remission at 1+ to 11+ months and are still being followed up. We conclude that all-trans retinoic acid is an effective inducer for attaining complete remission in APL. Volume 72, Issue 2, pp. 567-572, 08/01/1988 Copyright © 1988 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. O. Ballard III More Things in Heaven and Earth JAMA, August 19, 2009; 302(7): 723 - 724. [Full Text] [PDF] C. F. Burande, M. L. Heuze, I. Lamsoul, B. Monsarrat, S. 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Chen Tetra-arsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: a pilot report Blood, May 1, 2002; 99(9): 3136 - 3143. [Abstract] [Full Text] [PDF] M. M. Le Beau, S. Bitts, E. M. Davis, and S. C. Kogan Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia Blood, April 15, 2002; 99(8): 2985 - 2991. [Abstract] [Full Text] [PDF] J. L. Hummel, T. Zhang, R. A. Wells, and S. Kamel-Reid The Retinoic Acid Receptor {alpha} (RAR{alpha}) Chimeric Proteins PML-, PLZF-, NPM-, and NuMA-RAR{alpha} Have Distinct Intracellular Localization Patterns Cell Growth Differ., April 1, 2002; 13(4): 173 - 183. [Abstract] [Full Text] [PDF] J. L. Slack, S. Waxman, G. Tricot, M. S. Tallman, and C. D. Bloomfield Advances in the Management of Acute Promyelocytic Leukemia and Other Hematologic Malignancies with Arsenic Trioxide Oncologist, April 1, 2002; 7(90001): 1 - 13. [Abstract] [Full Text] [PDF] T. Maeno, T. Tanaka, Y. Sando, T. Suga, Y. Maeno, J. Nakagawa, T. Hosono, M. Sato, H. Akiyama, S. Kishi, et al. Stimulation of Vascular Endothelial Growth Factor Gene Transcription by all trans Retinoic Acid through Sp1 and Sp3 Sites in Human Bronchioloalveolar Carcinoma Cells Am. J. Respir. Cell Mol. Biol., February 1, 2002; 26(2): 246 - 253. [Abstract] [Full Text] [PDF] J. I. Jung, J. E. Choi, S. T. Hahn, C. K. Min, C. C. Kim, and S. H. Park Radiologic Features of All-Trans-Retinoic Acid Syndrome Am. J. Roentgenol., February 1, 2002; 178(2): 475 - 480. [Abstract] [Full Text] [PDF] M. S. Tallman, C. Nabhan, J. H. Feusner, and J. M. Rowe Acute promyelocytic leukemia: evolving therapeutic strategies Blood, February 1, 2002; 99(3): 759 - 767. [Abstract] [Full Text] [PDF] Q. Zhu, J.-W. Zhang, H.-Q. Zhu, Y.-L. Shen, M. Flexor, P.-M. Jia, Y. Yu, X. Cai, S. Waxman, M. Lanotte, et al. 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Takahashi Antitumor Efficacy in Vitro and in Vivo of Falconensones, a New Type of Polyene Clin. Cancer Res., November 1, 2001; 7(11): 3551 - 3558. [Abstract] [Full Text] [PDF] J. G. Jurcic, S. D. Nimer, D. A. Scheinberg, T. DeBlasio, R. P. Warrell Jr, and W. H. Miller Jr Prognostic significance of minimal residual disease detection and PML/RAR-alpha isoform type: long-term follow-up in acute promyelocytic leukemia Blood, November 1, 2001; 98(9): 2651 - 2656. [Abstract] [Full Text] [PDF] B. Cassinat, S. Chevret, F. Zassadowski, N. Balitrand, I. Guillemot, M.-L. Menot, L. Degos, P. Fenaux, and C. Chomienne In vitro all-trans retinoic acid sensitivity of acute promyelocytic leukemia blasts: a novel indicator of poor patient outcome Blood, November 1, 2001; 98(9): 2862 - 2864. [Abstract] [Full Text] [PDF] M. Danilenko, X. Wang, and G. P. Studzinski Carnosic Acid and Promotion of Monocytic Differentiation of HL60-G Cells Initiated by Other Agents J Natl Cancer Inst, August 15, 2001; 93(16): 1224 - 1233. [Abstract] [Full Text] [PDF] M. Okuno, T. Sano, R. Matsushima-Nishiwaki, S. Adachi, K. Akita, Y. Okano, S. Kojima, and H. Moriwaki Apoptosis Induction by Acyclic Retinoid: a Molecular Basis of 'Clonal Deletion' Therapy for Hepatocellular Carcinoma Jpn. J. Clin. Oncol., August 1, 2001; 31(8): 359 - 362. [Abstract] [Full Text] [PDF] D. Shan, A. K. Gopal, and O. W. Press Synergistic Effects of the Fenretinide (4-HPR) and Anti-CD20 Monoclonal Antibodies on Apoptosis Induction of Malignant Human B Cells Clin. Cancer Res., August 1, 2001; 7(8): 2490 - 2495. [Abstract] [Full Text] [PDF] R A Sharma, A J Gescher, K J O'Byrne, and W P Steward Familiar drugs may prevent cancer Postgrad. Med. J., August 1, 2001; 77(910): 492 - 497. [Abstract] [Full Text] [PDF] H. Maeda, S. Hori, H. Nishitoh, H. Ichijo, O. Ogawa, Y. Kakehi, and A. 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