|
|
 Previous Article | Table of Contents | Next Article 
Cooperative enhancement of F-cell formation in baboons treated with
erythropoietin and hydroxyurea
A Al-Khatti, T Papayannopoulou, G Knitter, EF Fritsch and G Stamatoyannopoulos
Department of Medicine, University of Washington, Seattle 98195.
Chronically anemic baboons on a continuous hydroxyurea regimen were treated
with pulsed doses of recombinant human erythropoietin (rHuEpo) to test
whether the combination of these two compounds, which individually induce
F-cell production, can enhance further F-cell output. A
low-F-cell-responding animal under chronic hydroxyurea treatment was given
three separate pulses of Epo and responded with F- reticulocyte increments
that were similar to the sum increments caused by either hydroxyurea alone
or rHuEpo alone. The same results were obtained in a high-F-responding
animal similarly treated. These findings suggest that rHuEpo and
hydroxyurea can increase F cell numbers in an additive fashion. It is
speculated that both compounds act through perturbation of erythroid
differentiation kinetics.
Volume 72,
Issue 2,
pp. 817-819,
08/01/1988
Copyright © 1988 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. C. Chang, L. Ye, and Y. W. Kan
Correction of the sickle cell mutation in embryonic stem cells
PNAS,
January 24, 2006;
103(4):
1036 - 1040.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. S. Pace, G. L. White, G. J. Dover, M. S. Boosalis, D. V. Faller, and S. P. Perrine
Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo
Blood,
December 15, 2002;
100(13):
4640 - 4648.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Samakoglu, E. Fattori, S. Lamartina, C. Toniatti, D. Stockholm, J. M. Heard, and D. Bohl
{beta}Minor-globin messenger RNA accumulation in reticulocytes governs improved erythropoiesis in {beta} thalassemic mice after erythropoietin complementary DNA electrotransfer in muscles
Blood,
April 15, 2001;
97(8):
2213 - 2220.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. BOHL and J.-M. HEARD
Delivering Erythropoietin through Genetically Engineered Cells
J. Am. Soc. Nephrol.,
November 1, 2000;
11
(90002):
S159 - S162.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. P. Rodgers, G. J. Dover, N. Uyesaka, C. T. Noguchi, A. N. Schechter, and A. W. Nienhuis
Augmentation by Erythropoietin of the Fetal-Hemoglobin Response to Hydroxyurea in Sickle Cell Disease
N. Engl. J. Med.,
January 14, 1993;
328(2):
73 - 80.
[Abstract]
[Full Text]
|
|
|
|
|
