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Vinculin, talin, and integrins are localized at specific adhesion sites of
malignant B lymphocytes
PC Marchisio, L Bergui, GC Corbascio, O Cremona, N D'Urso, M Schena, L Tesio and F Caligaris-Cappio
Dipartimento di Scienze Biomediche e Oncologia Umana, Universita di Torino,
Italy.
The microanatomy of the dot-shaped, close-contact sites called podosomes
and the mechanism of their formation have been investigated in vitro in the
malignant lymphocytes of B chronic lymphocytic leukemia (B-CLL). In this
paper the authors demonstrate that in B-CLL podosomes: (1) vinculin, talin,
and beta 2 integrin (CD18) rings surround an F- actin core; (2) the beta 1
integrin is localized within the F-actin core; (3) the beta 3 integrin is
not present. This distribution and organization of adhesion-related
molecules appears to be unique to B- CLL lymphocytes, since it has not been
observed in normal B cells. B- CLL adhesion and podosome formation are
inhibited by the synthetic peptide GRGDSP that contains the Arg-Gly-Asp
(RGD) sequence.
Volume 72,
Issue 2,
pp. 830-833,
08/01/1988
Copyright © 1988 by The American Society of Hematology
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