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Use of recombinant human granulocyte-macrophage colony-stimulating factor in autologous marrow transplantation for lymphoid malignancies

J Nemunaitis, JW Singer, CD Buckner, R Hill, R Storb, ED Thomas and FR Appelbaum

Fred Hutchinson Cancer Research Center, Seattle, WA.

The use of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) following autologous marrow transplantation for lymphoid malignancies was explored in a phase I/II dose escalation study. rhGM-CSF given as a 2-hour infusion daily for 14 days was well tolerated at doses up to 240 micrograms/m2/day. When compared with 86 disease-matched and treatment-matched historical controls, patients receiving greater than or equal to 60 micrograms/m2/day rhGM-CSF recovered neutrophil and platelet counts more rapidly, had fewer days with fever, and were discharged from the hospital sooner.

Volume 72, Issue 2, pp. 834-836, 08/01/1988
Copyright © 1988 by The American Society of Hematology


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