|
|
 Previous Article | Table of Contents | Next Article 
Prevention of HLA immunization with leukocyte-poor packed red cells and
platelet concentrates obtained by filtration
G Andreu, J Dewailly, C Leberre, MC Quarre, ML Bidet, R Tardivel, L Devers, Y Lam, E Soreau and C Boccaccio
Blood Bank, Paris Hotel-Dieu, France.
HLA immunization is a common complication of transfusion therapy in 30% to
60% of oncohematologic patients. Evidence shows that leukocytes present in
cellular blood products are the main component involved in the occurrence
of HLA immunization, and several studies showed that leukocyte-poor blood
products are less able to induce it. However, leukocyte-poor platelet
concentrates obtained by conventional techniques, ie, centrifugation,
frequently have a high level of remaining leukocytes. Cotton wool filter
Imugard IG 500 can be used to obtain leukocyte-poor cellular blood
products. The technique is easy to perform, even in an emergency, and can
be used with either packed RBCs or platelet concentrates. Means of 97%,
92%, and 76% elimination of leukocytes are obtained for packed RBCs, pooled
standard platelet concentrates, and single-donor platelet concentrates,
respectively. Patients were randomized to receive either standard (control
group) or filtered (leukocyte-poor group) blood products. Of 112 randomized
patients, 69 were evaluable, 35 in the control group and 34 in the
leukocyte-poor group. Both groups are comparable according to age,
diagnosis, sex ratio, previous transfusions, and pregnancies. There is a
significant difference in regard to the HLA immunization rate (31.4% in the
control v 11.7% in the leukocyte-poor group, P less than .05) and frequency
of refractoriness to platelet transfusions (46.6% v 11.7%, P less than
.05). We conclude that this filtration technique can be an efficient means
to reduce the HLA immunization rate in polytransfused oncohematologic
patients.
Volume 72,
Issue 3,
pp. 964-969,
09/01/1988
Copyright © 1988 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. J. Slichter, D. Fish, V. K. Abrams, L. Gaur, K. Nelson, and D. Bolgiano
Evaluation of different methods of leukoreduction of donor platelets to prevent alloimmune platelet refractoriness and induce tolerance in a canine transfusion model
Blood,
January 15, 2005;
105(2):
847 - 854.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Schoenfeld, M. Muhm, U. Doepfmer, A. Exadaktylos, and H. Radtke
Platelet Activity in Washed Platelet Concentrates
Anesth. Analg.,
July 1, 2004;
99(1):
17 - 20.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Karpinski, D. Pochinco, I. Dembinski, W. Laidlaw, J. Zacharias, and P. Nickerson
Leukocyte Reduction of Red Blood Cell Transfusions Does not Decrease Allosensitization Rates in Potential Kidney Transplant Candidates
J. Am. Soc. Nephrol.,
March 1, 2004;
15(3):
818 - 824.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Seftel, G. H. Growe, T. Petraszko, W. B. Benny, A. Le, C.-Y. Lee, J. J. Spinelli, H. J. Sutherland, P. Tsang, and D. E. Hogge
Universal prestorage leukoreduction in Canada decreases platelet alloimmunization and refractoriness
Blood,
January 1, 2004;
103(1):
333 - 339.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Naughton and C. A. Bashour
Mechanical Support After Cardiac Surgery
Seminars in Cardiothoracic and Vascular Anesthesia,
September 1, 2002;
6(3):
237 - 257.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. A. Schiffer, K. C. Anderson, C. L. Bennett, S. Bernstein, L. S. Elting, M. Goldsmith, M. Goldstein, H. Hume, J. J. McCullough, R. E. McIntyre, et al.
Platelet Transfusion for Patients With Cancer: Clinical Practice Guidelines of the American Society of Clinical Oncology
J. Clin. Oncol.,
March 1, 2001;
19(5):
1519 - 1538.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nomura, F. Okamae, M. Abe, M. Hosokawa, M. Yamaoka, T. Ohtani, S. Onishi, T. Matsuzaki, A. Teraoka, T. Ishida, et al.
Platelets Expressing P-Selectin and Platelet-Derived Microparticles in Stored Platelet Concentrates Bind to PSGL-1 on Filtrated Leukocytes
Clinical and Applied Thrombosis/Hemostasis,
October 1, 2000;
6(4):
213 - 221.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. W. Semple, E. R. Speck, D. Cosgrave, A. H. Lazarus, V. S. Blanchette, and J. Freedman
Extreme Leukoreduction of Major Histocompatibility Complex Class II Positive B Cells Enhances Allogeneic Platelet Immunity
Blood,
January 15, 1999;
93(2):
713 - 720.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
The Trial to Reduce Alloimmunization to Platelets
Leukocyte Reduction and Ultraviolet B Irradiation of Platelets to Prevent Alloimmunization and Refractoriness to Platelet Transfusions
N. Engl. J. Med.,
December 25, 1997;
337(26):
1861 - 1870.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
