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Next Article 
Desmopressin: a nontransfusional form of treatment for congenital and
acquired bleeding disorders [see comments]
PM Mannucci
A. Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milano,
Italy.
Desmopressin (1-deamino-8-D-arginine vasopressin, abbreviated DDAVP) is a
synthetic analogue of the antidiuretic hormone L-arginine vasopressin.
Because it can raise circulating levels of factor VIII coagulant activity
(FVIII) and von Willebrand factor and shorten the prolonged bleeding time,
DDAVP is established as a nontransfusional form of treatment for mild and
moderate hemophilia and von Willebrand disease. Recently, DDAVP has also
been purported to be useful for shortening the prolonged skin bleeding
times that occur with uremia, cirrhosis, and platelet dysfunctions of
various etiologies. Finally, there is evidence from controlled clinical
trials that DDAVP can reduce blood loss and transfusion requirements for
hemostatically normal individuals undergoing spinal fusion surgery and for
patients undergoing cardiopulmonary bypass surgery. The purpose of this
report is to review the therapeutic applications of DDAVP in congenital and
acquired bleeding disorders and to discuss areas in which further basic and
clinical research is needed.
Volume 72,
Issue 5,
pp. 1449-1455,
11/01/1988
Copyright © 1988 by The American Society of Hematology
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