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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sjamsoedin-Visser, L. J. Articles by Stoop, J. W. Search for Related Content PubMed PubMed Citation Articles by Sjamsoedin-Visser, L. J. Articles by Stoop, J. W. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Defective T suppressor-inducer cell function in human immune deficiency virus-seropositive hemophilia patients LJ Sjamsoedin-Visser, CJ Heijnen, BJ Zegers and JW Stoop Van Creveld Kliniek, Medisch Centrum Berg en Bosch, Bilthoven, The Netherlands. In human immune deficiency virus (HIV)-seropositive hemophilia patients, a low number of CD4 + lymphocytes is found, as well as a low CD4+/CD8+ ratio. In previous studies, it has been shown that antigen- specific T-helper cell (CD4+) function was present and no excessive antigen-specific T-suppressor cell (CD8+) function could be demonstrated. In this report, we studied another activity of CD4+ cells, namely the capacity to induce T-suppressor cell activity. The results clearly show a selective dysfunction of CD4+ suppressor-inducer (Tsi) cell function. Since these HIV-seropositive hemophilia patients showed the presence of activated B cells in the peripheral circulation refractory to antigen-specific T-helper cell signals and secreting specific antibodies spontaneously, we raised the hypothesis that the activated B cells in the patients activate the Tsi cells in vivo. This constant activation leads to a functional exhaustion of the Tsi cell pool. Volume 72, Issue 5, pp. 1474-1477, 11/01/1988 Copyright © 1988 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. S. Pappo, G. R. Buchanan, and A. Johnson Septic Arthritis in Children With Hemophilia Arch Pediatr Adolesc Med, October 1, 1989; 143(10): 1226 - 1228. [Abstract] [PDF]

	Copyright © 1988 by American Society of Hematology         Online ISSN: 1528-0020