SEARCH:   Advanced

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Andrew, M. Articles by Powers, P. Search for Related Content PubMed PubMed Citation Articles by Andrew, M. Articles by Powers, P. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Development of the human coagulation system in the healthy premature infant M Andrew, B Paes, R Milner, M Johnston, L Mitchell, DM Tollefsen, V Castle and P Powers Department of Pediatrics, McMaster University Medical Centre, Hamilton, Ontario, Canada. This study was designed to determine the postnatal development of the human coagulation system in the healthy premature infant. Consecutive mothers of healthy premature infants born at either St Joseph's Hospital or McMaster University Medical Centre in Hamilton were asked for consent. One hundred thirty-seven premature infants (30 to 36 weeks of gestational age) entered the study. The premature infants did not have any major health problems and did not require ventilation or supplemental oxygen. Demographic information and a 20-mL blood sample were obtained in the postnatal period on days 1, 5, 30, 90, and 180. Between 40 and 96 premature infants were studied on each day for each of the following tests: prothrombin time, activated partial thromboplastin time, thrombin clotting time, plasminogen; 13 factor assays [fibrinogen, II, V, VII, VIII, IX, X, XI, XII, XIII, high-mol-wt kininogen (HMWK), prekallikrein (PK), von Willebrand factor (vWF)] and eight inhibitors [antithrombin III (AT-III), heparin cofactor II, alpha 2-antiplasmin, alpha 2-macroglobulin, alpha 1-antitrypsin, C1 esterase inhibitor, protein C (PC), and protein S (PS)]. A combination of biologic and immunologic assays were used. Between 30 to 36 weeks there was a minimal effect of gestational age for levels of AT-III, PC, and factors II and X only; therefore, the entire data set was used to generate reference ranges for these components of the coagulation system for premature infants. Next, the results for the premature infants were compared with those of a previously published study in 118 fullterm infants and with those for adults. An effect of gestational age was shown for plasminogen, fibrinogen, factors II, V, VIII, IX, XI, XII, HMWK, and all eight inhibitors. In general, the postnatal maturation towards adult levels was accelerated in premature infants as compared with the fullterm infants. By 6 months of age, most components of the coagulation system in premature infants had achieved near adult values. Volume 72, Issue 5, pp. 1651-1657, 11/01/1988 Copyright © 1988 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. J. Manco-Johnson Hemostasis in the Neonate NeoReviews, March 1, 2008; 9(3): e119 - e123. [Abstract] [Full Text] [PDF] L. Raffini Thrombophilia in Children: Who to Test, How, When, and Why? Hematology, January 1, 2008; 2008(1): 228 - 235. [Abstract] [Full Text] [PDF] K.-L. Chan, R. G. Summerhayes, V. Ignjatovic, S. B. Horton, and P. T. Monagle Reference Values for Kaolin-Activated Thromboelastography in Healthy Children Anesth. Analg., December 1, 2007; 105(6): 1610 - 1613. [Abstract] [Full Text] [PDF] M.-C. Boffa and E. Lachassinne Review: Infant perinatal thrombosis and antiphospholipid antibodies: a review Lupus, August 1, 2007; 16(8): 634 - 641. [Abstract] [PDF] S. Kuhle, P. Eulmesekian, B. Kavanagh, P. Massicotte, P. Vegh, A. Lau, and L. G. Mitchell Lack of correlation between heparin dose and standard clinical monitoring tests in treatment with unfractionated heparin in critically III children Haematologica, April 1, 2007; 92(4): 554 - 557. [Abstract] [Full Text] [PDF] G. A. Dent, J. H. Herman, and J. E. Siegel Laboratory hematology ASH Self-Assessment Program, January 1, 2007; 2007(1): 444 - 465. [Full Text] [PDF] P. Clarke, S. J. Mitchell, R. Wynn, S. Sundaram, V. Speed, E. Gardener, D. Roeves, and M. J. Shearer Vitamin K Prophylaxis for Preterm Infants: A Randomized, Controlled Trial of 3 Regimens Pediatrics, December 1, 2006; 118(6): e1657 - e1666. [Abstract] [Full Text] [PDF] S. G Raja, S. Yousufuddin, F. Rasool, A. Nubi, M. Danton, and J. Pollock Impact of modified ultrafiltration on morbidity after pediatric cardiac surgery. Asian Cardiovasc Thorac Ann, August 1, 2006; 14(4): 341 - 350. [Abstract] [Full Text] [PDF] A. Chan, K. Jayasuriya, L. Berry, M. Roth-Kleiner, M. Post, and J. Belik Volutrauma activates the clotting cascade in the newborn but not adult rat Am J Physiol Lung Cell Mol Physiol, April 1, 2006; 290(4): L754 - L760. [Abstract] [Full Text] [PDF] P. Monagle, A. Chan, P. Massicotte, E. Chalmers, and A. D. Michelson Antithrombotic Therapy in Children*: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Chest, September 1, 2004; 126(3_suppl): 645S - 687S. [Abstract] [Full Text] [PDF] P. Monagle Anticoagulation in the young Heart, July 1, 2004; 90(7): 808 - 812. [Full Text] [PDF] S. C. Kettner, A. Pollak, M. Zimpfer, T. Seybold, A. R. Prusa, K. Herkner, and S. Kuhle Heparinase-Modified Thrombelastography in Term and Preterm Neonates Anesth. Analg., June 1, 2004; 98(6): 1650 - 1652. [Abstract] [Full Text] [PDF] M. M. Coleman, M. L. Spear, M. Finkelstein, K. H. Leef, S. A. Pearlman, C. Chien, S. M. Taylor, and S. E. McKenzie Short-Term Use of Umbilical Artery Catheters May Not Be Associated With Increased Risk for Thrombosis Pediatrics, April 1, 2004; 113(4): 770 - 774. [Abstract] [Full Text] [PDF] N A Murray and I A G Roberts Neonatal transfusion practice Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2004; 89(2): F101 - F107. [Abstract] [Full Text] [PDF] W Streif, G Goebel, A K C Chan, and M P Massicotte Use of low molecular mass heparin (enoxaparin) in newborn infants: a prospective cohort study of 62 patients Arch. Dis. Child. Fetal Neonatal Ed., September 1, 2003; 88(5): F365 - F370. [Abstract] [Full Text] [PDF] N Linder, B Shenkman, E Levin, L Sirota, T H Vishne, I Tamarin, R Dardik, D Lubin, N Savion, and D Varon Deposition of whole blood platelets on extracellular matrix under flow conditions in preterm infants Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2002; 86(2): F127 - F130. [Abstract] [Full Text] [PDF] T Avcin, R Cimaz, and P L Meroni Recent advances in antiphospholipid antibodies and antiphospholipid syndromes in pediatric populations Lupus, January 1, 2002; 11(1): 4 - 10. [Abstract] [PDF] T Avcin, R Cimaz, and P. Meroni Letter to the Editor Lupus, December 1, 2001; 10(12): 897 - 898. [PDF] M. Hauslerl, D. Hubner, H. Hornchen, E. G. Muhler, and U. Merzl Successful Thrombolysis of Inferior Vena Cava Thrombosis in a Preterm Neonate Clinical Pediatrics, February 1, 2001; 40(2): 105 - 108. [PDF] M. E. Andrew, P. Monagle, G. deVeber, and A. K.C. Chan Thromboembolic Disease and Antithrombotic Therapy in Newborns Hematology, January 1, 2001; 2001(1): 358 - 374. [Abstract] [Full Text] [PDF] P. Monagle, A. D. Michelson, E. Bovill, and M. Andrew Antithrombotic Therapy in Children Chest, January 1, 2001; 119(1_suppl): 344S - 370S. [Full Text] [PDF] S. A. Brown, M. Mitchell, J. A. Cutler, G. Moore, M. P. Smith, and G. F. Savidge Rapid Genetic Diagnosis in Neonatal Pulmonary Artery Thrombosis Caused by Homozygous Antithrombin Budapest 3 Clinical and Applied Thrombosis/Hemostasis, July 1, 2000; 6(3): 181 - 183. [Abstract] [PDF] C Gruenwald, V de Souza, A K. Chan, and M Andrew Whole blood heparin concentrations do not correlate with plasma antifactor Xa heparin concentrations in pediatric patients undergoing cardiopulmonary bypass Perfusion, May 1, 2000; 15(3): 203 - 209. [Abstract] [PDF] K. Kurachi and S. Kurachi Genetic Mechanisms of Age Regulation of Blood Coagulation : Factor IX Model Arterioscler. Thromb. Vasc. Biol., April 1, 2000; 20(4): 902 - 906. [Abstract] [Full Text] [PDF] L. A. Johnson-Robbins, J. C. Porter, and M. J. Horgan Splenic Rupture in a Newborn with Hemophilia A: Case Report and Revew of the Literature Clinical Pediatrics, March 1, 1999; 38(2): 117 - 119. [PDF] G. deVeber, P. Monagle, A. Chan, D. MacGregor, R. Curtis, S. Lee, P. Vegh, M. Adams, V. Marzinotto, M. Leaker, et al. Prothrombotic Disorders in Infants and Children With Cerebral Thromboembolism Arch Neurol, December 1, 1998; 55(12): 1539 - 1543. [Abstract] [Full Text] [PDF] B. SCHMIDT, P. GILLIE, L. MITCHELL, M. ANDREW, C. CACO, and R. ROBERTS A Placebo-controlled Randomized Trial of Antithrombin Therapy in Neonatal Respiratory Distress Syndrome Am. J. Respir. Crit. Care Med., August 1, 1998; 158(2): 470 - 476. [Abstract] [Full Text] [PDF] P. Monagle and M. Andrew Coagulation abnormalities after Fontan procedures J. Thorac. Cardiovasc. Surg., March 1, 1998; 115(3): 732 - 732. [Full Text] T. Duke, M. South, and A. Stewart Activation of the L-arginine nitric oxide pathway in severe sepsis Arch. Dis. Child., March 1, 1997; 76(3): 203 - 209. [Abstract] [Full Text] P. Rosenthal Assessing liver function and hyperbilirubinemia in the newborn Clin. Chem., January 1, 1997; 43(1): 228 - 234. [Abstract] [Full Text] [PDF]

	Copyright © 1988 by American Society of Hematology         Online ISSN: 1528-0020