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The myeloid blood cell differentiation-inducing protein MGI-2A is
interleukin-6
Y Shabo, J Lotem, M Rubinstein, M Revel, SC Clark, SF Wolf, R Kamen and L Sachs
Department of Genetics, Weizmann Institute of Science, Rehovot, Israel.
The mouse myeloid blood cell differentiation-inducing protein, macrophage
and granulocyte inducer, type 2A (MGI-2A), was purified, and the amino acid
sequence of a CNBr cleavage peptide (22 residues) was determined. This
amino acid sequence is identical to the sequence found in positions 73 to
94 of mouse interleukin-6 (IL-6). Recombinant mouse IL-6 protein induces
differentiation of mouse myeloid leukemic cells that are induced to
differentiation by MGI-2, and monoclonal antimouse- MGI-2 antibody, which
neutralizes MGI-2, also completely neutralizes this IL-6-induced
differentiation. These results show that the major type of mouse myeloid
differentiation-inducing protein (MGI-2A) and IL- 6 are very similar and
most likely identical proteins. Recombinant human IL-6 (also called
interferon-beta 2 or B-cell differentiation factor), which shows only a 41%
similarity to mouse IL-6, has 11 identical amino acid residues out of the
22 in the mouse MGI-2A peptide and also induces differentiation of the same
myeloid leukemic cells.
Volume 72,
Issue 6,
pp. 2070-2073,
12/01/1988
Copyright © 1988 by The American Society of Hematology
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