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 Previous Article | Table of Contents
Effects of recombinant human granulocyte colony-stimulating factor on
hematopoietic progenitor cells in cancer patients
U Duhrsen, JL Villeval, J Boyd, G Kannourakis, G Morstyn and D Metcalf
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne
Hospital, Victoria, Australia.
Hematopoietic progenitor cell levels were monitored in the peripheral blood
and bone marrow of 30 cancer patients receiving recombinant human
granulocyte-colony stimulating-factor (rG-CSF) in a phase I/II clinical
trial. The absolute number of circulating progenitor cells of
granulocyte-macrophage, erythroid, and megakaryocyte lineages showed a
dose-related increase up to 100-fold after four days of treatment with
rG-CSF and often remained elevated two days after the cessation of therapy.
The relative frequency of different types of progenitor cells in peripheral
blood remained unchanged. The frequency of progenitor cells in the marrow
was variable after rG-CSF treatment but in most patients was slightly
decreased. The responsiveness of bone marrow progenitor cells to
stimulation in vitro by rG-CSF and granulocyte- macrophage
colony-stimulating factor did not change significantly during rG-CSF
treatment. In patients nine days after treatment with melphalan and then
rG-CSF, progenitor cell levels were very low with doses of rG-CSF at or
below 10 micrograms/kg/d, but equaled or exceeded pretreatment values when
30 or 60 micrograms/kg/d of rG-CSF was given.
Volume 72,
Issue 6,
pp. 2074-2081,
12/01/1988
Copyright © 1988 by The American Society of Hematology
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