Rapid prenatal diagnosis of beta thalassemia using DNA amplification and
nonradioactive probes
SP Cai, CA Chang, JZ Zhang, RK Saiki, HA Erlich and YW Kan
Department of Medicine, University of California, San Francisco 94143-
0724.
We used in vitro DNA amplification by the polymerase chain reaction and
nonradioactive probes for prenatal diagnosis of beta thalassemia in Chinese
from the Guangdong province. Exact molecular diagnoses were made in all 20
fetuses studied over a 6-month period. We conclude that this method of
prenatal diagnosis for beta thalassemia is a viable approach in many parts
of the world where this disease is common.
Volume 73,
Issue 2,
pp. 372-374,
02/01/1989
Copyright © 1989 by The American Society of Hematology
