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Bone marrow transplantation for children with myelodysplastic syndromes
EC Guinan, NJ Tarbell, R Tantravahi and HJ Weinstein
Department of Pediatric, Dana-Farber Cancer Institute, Boston, MA 02115.
Therapeutic options for children with de novo or secondary myelodysplastic
syndromes (MDSs) are limited. We report the outcome of eight pediatric
patients (median age 12 years, range 3 to 19 years) with myelodysplasia who
underwent allogeneic bone marrow transplantation between 1984 and 1987. Two
of the eight children had developed secondary myelodysplasia after
alkylating agent-based combination chemotherapy. Five patients had clonal
chromosomal abnormalities, including four patients with monosomy 7. Seven
of eight patients engrafted. Two of these seven subsequently died of
complications of acute or chronic graft-v-host disease (GVHD), and a third
patient died at 21 months of pulmonary fibrosis. None of the patients have
had recurrence of disease. The four surviving patients remain in complete
remission at a median follow-up of 19 months (range 10 to 44 months).
Volume 73,
Issue 2,
pp. 619-622,
02/01/1989
Copyright © 1989 by The American Society of Hematology
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