|
|
 Previous Article | Table of Contents | Next Article 
Molecular genetic analysis of three AIDS-associated neoplasms of uncertain
lineage demonstrates their B-cell derivation and the possible pathogenetic
role of the Epstein-Barr virus
DM Knowles, G Inghirami, A Ubriaco and R Dalla-Favera
Department of Pathology, Columbia University College of Physicians and
Surgeons, New York 10032.
Each of three individuals with acquired immunodeficiency syndrome (AIDS)
developed a pleomorphic malignant neoplasm in which a precise
histopathologic diagnosis could not be rendered. In each case, the tumor
cells expressed leukocyte common antigen and a variable constellation of
antigens associated with B- and T-cell activation (HLA- DR, T9, T10, BL2,
BL3, Ki-24, BLAST-2). They lacked all B cell, T cell, myeloid, and monocyte
lineage-restricted antigens, resulting in their classification as
hematopoietic neoplasms of uncertain lineage. However, antigen receptor
gene rearrangement analysis demonstrated that each of these three neoplasms
exhibited clonal immunoglobulin heavy chain and kappa light chain gene
rearrangements and lacked T-cell receptor beta chain gene rearrangements
and therefore were B cell- derived non-Hodgkin's lymphomas (NHL)
representative of an equivalent, relatively mature stage of B-cell
differentiation. In contrast with most AIDS-associated NHLs, each of these
three neoplasms lacked c-myc gene rearrangements and contained Epstein-Barr
virus (EBV) proteins and/or sequences. These studies demonstrate that these
three AIDS- associated neoplasms of uncertain lineage exhibit a strikingly
similar constellation of distinctly uncommon morphologic, immunophenotypic,
and molecular genetic characteristics that distinguishes them substantially
from the vast majority of NHLs that have been reported to occur in
association with AIDS. The consistent presence of EBV proteins and/or DNA
sequences suggests that the Epstein-Barr virus played a pathogenetic role
in the development of these three AIDS-associated neoplasms. Finally, these
studies further illustrate the utility of antigen receptor gene
rearrangement analysis in the diagnosis and classification of hematopoietic
neoplasms of uncertain lineage.
Volume 73,
Issue 3,
pp. 792-799,
02/15/1989
Copyright © 1989 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
P. Gasperini, S. Sakakibara, and G. Tosato
Contribution of viral and cellular cytokines to Kaposi's sarcoma-associated herpesvirus pathogenesis
J. Leukoc. Biol.,
October 1, 2008;
84(4):
994 - 1000.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. A. Mack and B. Sugden
EBV Is Necessary for Proliferation of Dually Infected Primary Effusion Lymphoma Cells
Cancer Res.,
September 1, 2008;
68(17):
6963 - 6968.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K L Grogg, R F Miller, and A Dogan
HIV infection and lymphoma
J. Clin. Pathol.,
December 1, 2007;
60(12):
1365 - 1372.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-B. Chen, A. Rahemtullah, and E. Hochberg
Primary Effusion Lymphoma
Oncologist,
May 1, 2007;
12(5):
569 - 576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. Engels and J. J. Goedert
Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome and Cancer: Past, Present, and Future
J Natl Cancer Inst,
March 16, 2005;
97(6):
407 - 409.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. T. Heidecker and C. Strange
Primary Effusion Lymphoma in a non-HIV Patient: a Case Report and Discussion of Treatment Modalities
Chest Meeting Abstracts,
October 1, 2004;
126(4):
981S - 981S.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. V. Ablashi, L. G. Chatlynne, J. E. Whitman Jr., and E. Cesarman
Spectrum of Kaposi's Sarcoma-Associated Herpesvirus, or Human Herpesvirus 8, Diseases
Clin. Microbiol. Rev.,
July 1, 2002;
15(3):
439 - 464.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. L. Perez and S. Rudoy
Anti-CD20 Monoclonal Antibody Treatment of Human Herpesvirus 8-Associated, Body Cavity-Based Lymphoma with an Unusual Phenotype in a Human Immunodeficiency Virus-Negative Patient
Clin. Vaccine Immunol.,
September 1, 2001;
8(5):
993 - 996.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Keller, E. J. Schattner, and E. Cesarman
Inhibition of NF-kappa B induces apoptosis of KSHV-infected primary effusion lymphoma cells
Blood,
October 1, 2000;
96(7):
2537 - 2542.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Gradoville, J. Gerlach, E. Grogan, D. Shedd, S. Nikiforow, C. Metroka, and G. Miller
Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 50/Rta Protein Activates the Entire Viral Lytic Cycle in the HH-B2 Primary Effusion Lymphoma Cell Line
J. Virol.,
July 1, 2000;
74(13):
6207 - 6212.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
F. Pica, A. Volpi, A. Serafino, M. Fraschetti, O. Franzese, and E. Garaci
Autocrine nerve growth factor is essential for cell survival and viral maturation in HHV-8-infected primary effusion lymphoma cells
Blood,
May 1, 2000;
95(9):
2905 - 2912.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Damania, J.-K. Choi, and J. U. Jung
Signaling Activities of Gammaherpesvirus Membrane Proteins
J. Virol.,
February 15, 2000;
74(4):
1593 - 1601.
[Full Text]
|
|
|
|
|
|
|
K. D. Jones, Y. Aoki, Y. Chang, P. S. Moore, R. Yarchoan, and G. Tosato
Involvement of Interleukin-10 (IL-10) and Viral IL-6 in the Spontaneous Growth of Kaposi's Sarcoma Herpesvirus-Associated Infected Primary Effusion Lymphoma Cells
Blood,
October 15, 1999;
94(8):
2871 - 2879.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. G.S. Chirivi, G. Taraboletti, M. R. Bani, L. Barra, G. Piccinini, M. Giacca, F. Bussolino, and R. Giavazzi
Human Immunodeficiency Virus-1 (HIV-1)-Tat Protein Promotes Migration of Acquired Immunodeficiency Syndrome-Related Lymphoma Cells and Enhances Their Adhesion to Endothelial Cells
Blood,
September 1, 1999;
94(5):
1747 - 1754.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Staskus, R. Sun, G. Miller, P. Racz, A. Jaslowski, C. Metroka, H. Brett-Smith, and A. T. Haase
Cellular Tropism and Viral Interleukin-6 Expression Distinguish Human Herpesvirus 8 Involvement in Kaposi's Sarcoma, Primary Effusion Lymphoma, and Multicentric Castleman's Disease
J. Virol.,
May 1, 1999;
73(5):
4181 - 4187.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
N. Dupin, C. Fisher, P. Kellam, S. Ariad, M. Tulliez, N. Franck, E. van Marck, D. Salmon, I. Gorin, J.-P. Escande, et al.
Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma
PNAS,
April 13, 1999;
96(8):
4546 - 4551.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Matolcsy, R. G. Nador, E. Cesarman, and D. M. Knowles
Immunoglobulin VH Gene Mutational Analysis Suggests that Primary Effusion Lymphomas Derive from Different Stages of B Cell Maturation
Am. J. Pathol.,
November 1, 1998;
153(5):
1609 - 1614.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Asou, J. W. Said, R. Yang, R. Munker, D. J. Park, N. Kamada, and H. P. Koeffler
Mechanisms of Growth Control of Kaposi's Sarcoma-Associated Herpes Virus-Associated Primary Effusion Lymphoma Cells
Blood,
April 1, 1998;
91(7):
2475 - 2481.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Boshoff, S.-J. Gao, L. E. Healy, S. Matthews, A. J. Thomas, L. Coignet, R. A. Warnke, J. A. Strauchen, E. Matutes, O. W. Kamel, et al.
Establishing a KSHV+ Cell Line (BCP-1) From Peripheral Blood and Characterizing Its Growth in Nod/SCID Mice
Blood,
March 1, 1998;
91(5):
1671 - 1679.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Gaidano, A. Gloghini, V. Gattei, M.F. Rossi, A.M. Cilia, C. Godeas, M. Degan, T. Perin, V. Canzonieri, D. Aldinucci, et al.
Association of Kaposi's Sarcoma-Associated Herpesvirus-Positive Primary Effusion Lymphoma With Expression of the CD138/Syndecan-1 Antigen
Blood,
December 15, 1997;
90(12):
4894 - 4900.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. G. Horenstein, R. G. Nador, A. Chadburn, E. M. Hyjek, G. Inghirami, D. M. Knowles, and E. Cesarman
Epstein-Barr Virus Latent Gene Expression in Primary Effusion Lymphomas Containing Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus-8
Blood,
August 1, 1997;
90(3):
1186 - 1191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.J. Delecluse, I. Anagnostopoulos, F. Dallenbach, M. Hummel, T. Marafioti, U. Schneider, D. Huhn, A. Schmidt-Westhausen, P.A. Reichart, U. Gross, et al.
Plasmablastic Lymphomas of the Oral Cavity: A New Entity Associated With the Human Immunodeficiency Virus Infection
Blood,
February 15, 1997;
89(4):
1413 - 1420.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Miller, M. O. Rigsby, L. Heston, E. Grogan, R. Sun, C. Metroka, J. A. Levy, S.-J. Gao, Y. Chang, and P. Moore
Antibodies to Butyrate-Inducible Antigens of Kaposi's Sarcoma-Associated Herpesvirus in Patients with HIV-1 Infection
N. Engl. J. Med.,
May 16, 1996;
334(20):
1292 - 1297.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Cesarman, Y. Chang, P. S. Moore, J. W. Said, and D. M. Knowles
Kaposi's Sarcoma-Associated Herpesvirus-Like DNA Sequences in AIDS-Related Body-Cavity-Based Lymphomas
N. Engl. J. Med.,
May 4, 1995;
332(18):
1186 - 1191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
