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A novel translocation, t(2;5)(p23;q35), in childhood phagocytic large T-
cell lymphoma mimicking malignant histiocytosis
Y Kaneko, G Frizzera, S Edamura, N Maseki, M Sakurai, Y Komada, M Sakurai, H Tanaka, M Sasaki and T Suchi
Department of Laboratory Medicine, Saitama Cancer Center, Ina, Japan.
We report a novel chromosome translocation--t(2;5)(p23;q35) or its variant,
t(2;5;13)(p23;q35;q12)--in 3 patients with peripheral T-cell lymphoma. All
3 were female children who had peripheral lymphadenopathy without
organomegaly and underwent complete remission with or without chemotherapy.
Their tumors were characterized histologically by predominant large cells,
at times showing phagocytosis, and immunologically by peripheral T-cell
phenotype and expression of Ki-1 antigen and epithelial membrane antigen
(EMA). Since the same translocation has been reported in the literature in
4 patients with malignant histiocytosis (MH), and our patients had
histologic features suggestive of that disease, it is likely that many
tumors previously interpreted as MH are actually phagocytic large T-cell
lymphoma carrying this translocation.
Volume 73,
Issue 3,
pp. 806-813,
02/15/1989
Copyright © 1989 by The American Society of Hematology
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