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Molecular organization of the cytokine gene cluster, involving the human
IL-3, IL-4, IL-5, and GM-CSF genes, on human chromosome 5
BH van Leeuwen, ME Martinson, GC Webb and IG Young
Medical Molecular Biology Group, John Curtin School of Medical Research,
Canberra, Australia.
The human genes for the hematopoietic growth factors interleukin-3 (IL- 3),
IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) have
been mapped to 5q23-31. We present in situ hybridization evidence that the
human IL-4 gene is located at 5q23.3-31.2, suggesting that the four
cytokine genes may be closely linked. We used pulsed-field gel
electrophoresis to prepare subchromosomal restriction maps surrounding
these genes to define this possible linkage more precisely. The IL-4 and
IL-5 genes are tightly linked, being 90 to 240 kilobases (kb) apart, as has
been shown for the IL-3 and GM-CSF genes, which are only 9 kb apart.
Possible overlap of the map containing the IL-4 and IL-5 genes with
restriction sites 5' to the IL-3 gene suggests that the four cytokine genes
may be localized within 500 kb of each other. The endothelial cell growth
factor gene (ECGF), which has also been localized to the 5q31 region, did
not appear to be close to the cytokine genes. Linkage of the IL-3, IL-4,
IL-5, and GM-CSF genes has important implications in the evolutionary
origin and regulation of expression of these genes. The four cytokine genes
are located in the region of the long arm of chromosome 5, which is deleted
in the 5q- anomaly. The present study provides a basis for further
investigations of this disorder.
Volume 73,
Issue 5,
pp. 1142-1148,
04/01/1989
Copyright © 1989 by The American Society of Hematology
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