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Human normal CD5+ B lymphocytes can be induced to differentiate to CD5- B lymphocytes with germinal center cell features

F Caligaris-Cappio, M Riva, L Tesio, M Schena, G Gaidano and L Bergui

Dipartimento di Scienze Biomediche e Oncologia Umana, Universita di Torino, Italy.

A significant proportion of cord blood CD5+ B cells express the activation molecules CD23, CD25, and transferrin receptor; react with the cell-cycle-associated monoclonal antibody (MoAb) Ki67; can be induced to enter the S phase of cell cycle by interleukin-2 (IL-2), IL- 4, or low-molecular-weight B-cell growth factor (Imw-BCGF) and, exposed to IL-1 and IL-2, acquire the features (sIgD-, CD5-, CD10+, CD38+) of B blasts proliferating in the germinal centers of secondary follicles. These findings indicate that CD5+ B cells are preactivated and, in the proper microenvironment, may give rise to CD5- B cells.

Volume 73, Issue 5, pp. 1259-1263, 04/01/1989
Copyright © 1989 by The American Society of Hematology


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