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Constitutive expression of the interleukin-6 gene in chronic lymphocytic leukemia

A Biondi, V Rossi, R Bassan, T Barbui, S Bettoni, M Sironi, A Mantovani and A Rambaldi

Clinica Pediatrica Universita di Milano, Ospedale S. Gerardo, Italy.

Interleukin-6 (IL-6) is a pleiotropic lymphokine active as a growth factor on B-cell hybridomas and plasmacytomas and found to be identical with B-cell stimulatory factor 2, interferon beta 2, 26-Kd protein, and hepatocytes stimulating factor. IL-6 gene expression was investigated in fresh human chronic lymphocytic leukemia (B-CLL) and in acute lymphoblastic leukemia (ALL) by Northern blot analysis using a specific cDNA probe. 1.3-kb IL-6 transcript was found in six out of 11 B-CLL patients, while no hybridization was observed in ten cases of ALL of both T- and B-cell origin. The constitutive expression of IL-6 transcripts was associated with production of a biologically active protein as determined by using the IL-6-dependent 7TD1 cell line. It remains to be elucidated whether IL-6 gene expression is indeed important in the regulation of B-CLL growth or in its clinical manifestation.

Volume 73, Issue 5, pp. 1279-1284, 04/01/1989
Copyright © 1989 by The American Society of Hematology


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