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The t(5;14) chromosomal translocation in a case of acute lymphocytic
leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain
gene
JC Grimaldi and TC Meeker
Department of Medicine, University of California, San Francisco 94121.
Chromosomal translocations have proven to be important markers of the
genetic abnormalities central to the pathogenesis of cancer. By cloning
chromosomal breakpoints one can identify activated proto-oncogenes. We have
studied a case of B-lineage acute lymphocytic leukemia (ALL) that was
associated with peripheral blood eosinophilia. The chromosomal
translocation t(5;14) (q31;q32) from this sample was cloned and studied at
the molecular level. This translocation joined the immunoglobulin heavy
chain joining (Jh) region to the promotor region of the interleukin-3
(IL-3) gene in opposite transcriptional orientations. The data suggest that
activation of the IL-3 gene by the enhancer of the immunoglobulin heavy
chain gene may play a central role in the pathogenesis of this leukemia and
the associated eosinophilia.
Volume 73,
Issue 8,
pp. 2081-2085,
06/01/1989
Copyright © 1989 by The American Society of Hematology
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