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Chromosomal abnormalities in Hodgkin's disease
HC Schouten, WG Sanger, M Duggan, DD Weisenburger, KA MacLennan and JO Armitage
Department of Internal Medicine, University of Nebraska Medical Center,
Omaha.
Numerous neoplastic states have associated or causal cytogenetic
abnormalities. In some cancers, specific chromosomal abnormalities appear
to correlate with the clinical characteristics and prognosis. Cytogenetic
analysis of Hodgkin's disease is thought to be technically difficult and
only a small number of cases with evaluable results have been reported. We
have attempted cytogenetic studies of lymph nodes from 37 patients with
Hodgkin's disease. In 29 of the 37 patients (78%), successful chromosomal
analysis was accomplished. Chromosomal abnormalities were found in 13
patients (45%); five of these patients had been previously treated with
chemotherapy. Numerical changes were found in all patients, most commonly
involving chromosomes 5, 9, 15, 18, 22, X, and marker chromosomes. Seven
patients also had structural abnormalities. The breakpoints 4q32-34, 6q24,
12q13, 12q23-24, and 13p11-13 were each seen in at least two patients. All
but two patients had an admixture of normal cells. Three patients had two
or more clones, and one had subclones. No statistically significant
correlations between chromosomal abnormalities and clinical characteristics
were demonstrated, although the number of patients in each subgroup was
small. We conclude that chromosomal studies of Hodgkin's disease are likely
to be successful. Additional studies are needed to correlate the
karyotypical abnormalities in Hodgkin's disease with clinical and
biological characteristics.
Volume 73,
Issue 8,
pp. 2149-2154,
06/01/1989
Copyright © 1989 by The American Society of Hematology
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