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Lack of involvement of the c-fms and N-myc genes by chromosomal
translocation t(2;5)(p23;q35) common to malignancies with features of
so-called malignant histiocytosis
R Morgan, SD Smith, BK Hecht, V Christy, JD Mellentin, R Warnke and ML Cleary
Genetics Center of Southwest Biomedical Research Institute, Scottsdale, AZ.
We report the molecular, cytogenetic, and immunologic characterization of
three hematologic malignancies that contained characteristic t(2;5)
chromosomal translocations. The clinicopathologic features in all three
cases fit the disease spectrum of so-called malignant histiocytosis (MH).
All cases expressed activation antigens including Ki-1 (CD 30), but no
lineage-restricted pattern of cellular antigen expression was observed.
Cell lines SUP-M2 and SU-DHL-1 established from two of the cases showed
rearranged beta T-cell receptor (beta TCR) genes nonproductive of
full-length beta TCR mRNA and therefore not helpful in unequivocal
establishment of lineage derivation. The common cytogenetic feature was a
reciprocal translocation between chromosomes 2 and 5, involving bands 2p23
and 5q35 near the reported chromosomal locations of the N-myc and c-fms
genes, respectively. Normal-sized and truncated c-fms RNAs were observed in
both cell lines, whereas no N-myc transcripts were detected. Sequence
analysis of the truncated fms RNA showed that it consisted of the 3' half
of the c-fms mRNA, but its derivation was not the result of a structural
alteration of the c-fms gene. Our studies show that the t(2;5) does not
involve the N-myc and c- fms protooncogenes and that this cytogenetic
abnormality may be characteristic of a subset of primitive malignancies
with an indeterminate lineage but with clinicopathologic features of
so-called MH.
Volume 73,
Issue 8,
pp. 2155-2164,
06/01/1989
Copyright © 1989 by The American Society of Hematology
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