|
|
 Previous Article | Table of Contents | Next Article 
Antibody-radionuclide conjugates as part of a myeloablative preparative
regimen for marrow transplantation
FR Appelbaum, P Brown, B Sandmaier, C Badger, F Schuening, T Graham and R Storb
Fred Hutchinson Cancer Research Center, Division of Clinical Research,
Seattle, WA 98104.
The behaviors of an anti-Ia antibody (7.2) and an antibody directed at a
lymphocyte adhesion molecule (S.5) radiolabeled with 131I were studied in
normal dogs. Antibody 7.2 localized to spleen and, to a lesser extent, to
marrow and lymph nodes. Antibody S.5 rapidly localized to marrow and
spleen, achieving tissue/blood ratios greater than 6:1 within three hours
of injection that were maintained for at least 48 hours. Prior treatment
with cyclophosphamide (CY) markedly altered the distribution of S.5 but had
much less effect on the distribution of 7.2 and almost no effect on the
distribution of a control antibody. When animals were treated with
increasing doses of 131I labeled to S.5, lethal myelosuppression occurred
when a dose of 6 mCi/kg was reached. At this dose, the otherwise lethal
effects of 131I could be reversed with autologous marrow transplant
support.
Volume 73,
Issue 8,
pp. 2202-2208,
06/01/1989
Copyright © 1989 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. J. Green, J. M. Pagel, E. R. Nemecek, Y. Lin, A. Kenoyer, A. Pantelias, D. K. Hamlin, D. S. Wilbur, D. R. Fisher, J. G. Rajendran, et al.
Pretargeting CD45 enhances the selective delivery of radiation to hematolymphoid tissues in nonhuman primates
Blood,
August 6, 2009;
114(6):
1226 - 1235.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. A. Bethge, D. S. Wilbur, R. Storb, D. K. Hamlin, E. B. Santos, M. W. Brechbiel, D. R. Fisher, and B. M. Sandmaier
Selective T-cell ablation with bismuth-213-labeled anti-TCR{alpha}{beta} as nonmyeloablative conditioning for allogeneic canine marrow transplantation
Blood,
June 15, 2003;
101(12):
5068 - 5075.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. M. Sandmaier, R. Storb, K. L. Bennett, F. R. Appelbaum, and E. B. Santos
Epitope Specificity of CD44 for Monoclonal Antibody-Dependent Facilitation of Marrow Engraftment in a Canine Model
Blood,
May 1, 1998;
91(9):
3494 - 3502.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
