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Life-threatening intracranial bleeding associated with the presence of an antifactor VII autoantibody

A Delmer, MH Horellou, G Andreu, T Lecompte, F Rossi, MD Kazatchkine, M Samama and R Zittoun

Service d'Hematologie, Laboratoire Central d'Hematologie, Hotel-Dieu, Paris, France.

This is a report of a 62-year-old male patient who had a bleeding disorder due to the presence of a factor VII (proconvertin) inhibitor. After treatment with a high-dose intravenous (IV) immunoglobulin failed and a life-threatening intracranial hemorrhage occurred, plasma exchanges were performed and immunosuppressive therapy was given. The factor VII inhibitor promptly disappeared, and the patient's parameters of hemostasis became normal. Even though a relapse occurred some months later, the patient responded to immunosuppressive therapy. No underlying disorder was evidenced after 17 months of follow-up.

Volume 74, Issue 1, pp. 229-232, 07/01/1989
Copyright © 1989 by The American Society of Hematology


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  Copyright © 1989 by American Society of Hematology         Online ISSN: 1528-0020