|
|
 Previous Article | Table of Contents | Next Article 
Detection of a human CFC with a high proliferative potential
IK McNiece, FM Stewart, DM Deacon, DS Temeles, KM Zsebo, SC Clark and PJ Quesenberry
School of Medicine, University of Virginia, Charlottesville.
Colony forming cells (CFC) with high proliferative potential have been
detected in nutrient agar cultures of human bone marrow cells containing
recombinant human interleukin-3 (IL-3) and granulocyte macrophage colony
stimulating factor (GM-CSF). These CFC were detected by the formation of
large colonies with diameters greater than 0.5 mm and containing
approximately 50,000 cells after 28 days incubation. The incidence of these
CFC was only two in 100,000 normal bone marrow cells; however, bone marrow
from patients treated with 5-fluorouracil contained up to sevenfold higher
numbers of these CFC. The characteristics of these CFC,
multifactor-responsive progenitors with high proliferative potential,
requiring a prolonged growth period in culture and showing a relative
preservation in marrow from individuals pretreated with 5-fluorouracil, are
consistent with a human cell type equivalent to the primitive murine
progenitor termed HPP-CFC.
Volume 74,
Issue 2,
pp. 609-612,
08/01/1989
Copyright © 1989 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. A. Ingram, L. E. Mead, D. B. Moore, W. Woodard, A. Fenoglio, and M. C. Yoder
Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells
Blood,
April 1, 2005;
105(7):
2783 - 2786.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Ingram, L. E. Mead, H. Tanaka, V. Meade, A. Fenoglio, K. Mortell, K. Pollok, M. J. Ferkowicz, D. Gilley, and M. C. Yoder
Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood
Blood,
November 1, 2004;
104(9):
2752 - 2760.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Hess, K. D. Levac, F. N. Karanu, M. Rosu-Myles, M. J. White, L. Gallacher, B. Murdoch, M. Keeney, P. Ottowski, R. Foley, et al.
Functional analysis of human hematopoietic repopulating cells mobilized with granulocyte colony-stimulating factor alone versus granulocyte colony-stimulating factor in combination with stem cell factor
Blood,
July 18, 2002;
100(3):
869 - 878.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Blazsek, J. Chagraoui, and B. Peault
Ontogenic emergence of the hematon, a morphogenetic stromal unit that supports multipotential hematopoietic progenitors in mouse bone marrow
Blood,
December 1, 2000;
96(12):
3763 - 3771.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Miyoshi, K. A. Smith, D. E. Mosier, I. M. Verma, and B. E. Torbett
Transduction of Human CD34+ Cells That Mediate Long-Term Engraftment of NOD/SCID Mice by HIV Vectors
Science,
January 29, 1999;
283(5402):
682 - 686.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. L. Jackson and L. A. Loeb
The Mutation Rate and Cancer
Genetics,
April 1, 1998;
148(4):
1483 - 1490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. J. Hogan, E. J. Shpall, O. McNulty, I. McNiece, J. E. Dick, L. D. Shultz, and G. Keller
Engraftment and Development of Human CD34+-Enriched Cells From Umbilical Cord Blood in NOD/LtSz-scid/scid Mice
Blood,
July 1, 1997;
90(1):
85 - 96.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
