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Platelet-melanoma cell interaction is mediated by the glycoprotein IIb- IIIa complex

H Boukerche, O Berthier-Vergnes, E Tabone, JF Dore, LL Leung and JL McGregor

Faculte de Medicine Alexis Carrel, INSERM Unite 63, Lyon, France.

A human malignant melanoma cell line (M3Dau) was observed by electron microscopy to interact directly with human platelets and induced platelet aggregation. Fab fragments of a monoclonal antibody MoAb (LYP18), directed against the platelet glycoprotein (GP) IIb-IIIa complex, inhibited platelet-melanoma interactions and platelet-platelet aggregation. M3Dau melanoma cells bind LYP 18 and synthesize IIb-IIIa- like GPs. When the melanoma cells were preincubated with LYP 18, tumor- platelet interaction did not occur, suggesting that the interaction may be mediated by the IIb-IIIa-like GPs present on the melanoma cell surface. Glanzmann's thrombasthenic platelets, lacking GPIIb and IIIa, did not interact with melanoma cells, indicating that the platelet GPIIb-IIIa complex is also necessary for the platelet-melanoma cell interaction. This work demonstrates the importance of the IIb-IIIa-like GPs, present on M3Dau melanoma cells, in mediating tumor-platelet interactions.

Volume 74, Issue 2, pp. 658-663, 08/01/1989
Copyright © 1989 by The American Society of Hematology


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  Copyright © 1989 by American Society of Hematology         Online ISSN: 1528-0020