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Demonstration of monoclonal EBV genomes in Hodgkin's disease and Ki-1-
positive anaplastic large cell lymphoma by combined Southern blot and in
situ hybridization [see comments]
I Anagnostopoulos, H Herbst, G Niedobitek and H Stein
Institute of Pathology, Free University Berlin, West Germany.
Forty-two cases of Hodgkin's disease (HD) and 22 cases of Ki-1-positive
anaplastic large cell (Ki-1 + ALC) lymphoma were examined by Southern
blotting for the presence of Epstein-Barr virus (EBV) DNA. Seven cases of
HD and one case of Ki-1 + ALC lymphoma scored positive with a probe
specific for the internal repetitive region of the EBV genome.
Subsequently, these viral genomes could be demonstrated to be monoclonal in
origin using an EBV terminal region DNA probe. In situ hybridization
revealed that in two HD cases, the EBV infected cells had the distinct
morphology of Hodgkin and Reed-Sternberg cells, thus suggesting a direct
pathoetiological relationship between EBV and some cases of HD.
Volume 74,
Issue 2,
pp. 810-816,
08/01/1989
Copyright © 1989 by The American Society of Hematology
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