SEARCH:   Advanced

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Frazier, D. Articles by Stafford, D. W. Search for Related Content PubMed PubMed Citation Articles by Frazier, D. Articles by Stafford, D. W. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Mapping of monoclonal antibodies to human factor IX D Frazier, KJ Smith, WF Cheung, J Ware, SW Lin, AR Thompson, H Reisner, SP Bajaj and DW Stafford Department of Biology, University of North Carolina, Chapel Hill 27599- 3280. We used recombinant DNA techniques to map a panel of six monoclonal antibodies (MoAbs) to regions of the human factor IX molecule. A-2 maps to 17 amino acids at the amino terminus of the heavy chain of IXa; 2D5, an inhibitor of clotting, is defined to 36 amino acids of the first EGF- like domain of human factor IX. A-4, A-5, C10D, and FXC008 all map to a region of the heavy chain containing amino acids 180 through 310, suggesting an immunodominant site. FXC008 has been reported to interfere with binding of factor IXa to factor VIII:Ca. Volume 74, Issue 3, pp. 971-977, 08/15/1989 Copyright © 1989 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D.-Y. Jin, T.-P. Zhang, T. Gui, D. W. Stafford, and P. E. Monahan Creation of a mouse expressing defective human factor IX Blood, September 15, 2004; 104(6): 1733 - 1739. [Abstract] [Full Text] [PDF] F. S. London, M. Marcinkiewicz, and P. N. Walsh A Subpopulation of Platelets Responds to Thrombin- or SFLLRN-stimulation with Binding Sites for Factor IXa J. Biol. Chem., May 7, 2004; 279(19): 19854 - 19859. [Abstract] [Full Text] [PDF] D J Bowen Haemophilia A and haemophilia B: molecular insights Mol. Pathol., April 1, 2002; 55(2): 127 - 144. [Abstract] [Full Text] [PDF] D J Bowen Haemophilia A and haemophilia B: molecular insights Mol. Pathol., February 1, 2002; 55(1): 1 - 18. [Abstract] [Full Text] [PDF] A. Mathur and S. P. Bajaj Protease and EGF1 Domains of Factor IXa Play Distinct Roles in Binding to Factor VIIIa. IMPORTANCE OF HELIX 330 (HELIX 162 IN CHYMOTRYPSIN) OF PROTEASE DOMAIN OF FACTOR IXa IN ITS INTERACTION WITH FACTOR VIIIa J. Biol. Chem., June 25, 1999; 274(26): 18477 - 18486. [Abstract] [Full Text] [PDF] A. S. Wolberg, D. W. Stafford, and D. A. Erie Human Factor IX Binds to Specific Sites on the Collagenous Domain of Collagen IV J. Biol. Chem., July 4, 1997; 272(27): 16717 - 16720. [Abstract] [Full Text] [PDF] P. J. Larson, S. A. Stanfield-Oakley, W. J. VanDusen, C. K. Kasper, K. J. Smith, D. M. Monroe, and K. A. High Structural Integrity of the [IMAGE]-Carboxyglutamic Acid Domain of Human Blood Coagulation Factor IXa Is Required for Its Binding to Cofactor VIIIa J. Biol. Chem., February 16, 1996; 271(7): 3869 - 3876. [Abstract] [Full Text] [PDF] L. M. O'Brien, L. V. Medved, and P. J. Fay Localization of Factor IXa and Factor VIIIa Interactive Sites J. Biol. Chem., November 10, 1995; 270(45): 27087 - 27092. [Abstract] [Full Text] [PDF]

	Copyright © 1989 by American Society of Hematology         Online ISSN: 1528-0020