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Interleukin-4 stimulates human monocytes to produce tissue-type plasminogen
activator
PH Hart, DR Burgess, GF Vitti and JA Hamilton
University of Melbourne, Department of Medicine, Parkville, Victoria,
Australia.
Tissue-type plasminogen activator (t-PA) is involved in the lysis of blood
clots (fibrinolysis) and is used clinically for this purpose. Endothelial
cells are one source of the t-PA present in blood. We report here that
interleukin-4 (IL-4) (0.1 to 0.25 U/mL; 1 to 3 x 10(- 11) mol/L), but not
interferon-gamma (IFN-gamma), elevates t-PA messenger (m)RNA expression and
secretion of t-PA activity by human monocytes, with the maximum response at
2.5 U/mL. Supernatant t-PA activity was detected within three hours of
exposure to IL-4 and maximum activity within six hours. Thus, IL-4 may
control fibrin deposition at sites of inflammation during cell-mediated
immune responses, as well as having a therapeutic role in thrombolysis.
Volume 74,
Issue 4,
pp. 1222-1225,
09/01/1989
Copyright © 1989 by The American Society of Hematology
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