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Increased circulating CSF-1 (M-CSF) in myeloproliferative disease:
association with myeloid metaplasia and peripheral bone marrow extension
HS Gilbert, V Praloran and ER Stanley
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY
10461.
Myeloproliferative disease (MPD) is heterogeneous in phenotypic expression
and may display features consistent with expansion and activation of the
monocyte/macrophage population during its course. The role of
colony-stimulating factor-1 (CSF-1) in the pathophysiology of MPD was
investigated by measuring circulating CSF-1 levels and examining their
relationship to disease phenotype. Serum CSF-1 concentrations, measured by
radioimmunoassay, were elevated in all MPD phenotypes. CSF-1 levels
differed significantly between groups of patients with essential
thrombocythemia, polycythemia vera, and postpolycythemic or agnogenic
myeloid metaplasia (in ascending order). CSF-1 serum levels were positively
correlated with spleen size and the degree of peripheral bone marrow
extension, determined by scintigraphy using a macrophage-seeking isotope.
There was no correlation between CSF-1 concentration and circulating levels
of erythrocytes, neutrophils or platelets, or the presence of bone marrow
fibrosis. Elevated serum CSF-1 levels appear to be associated with an
expanded monocyte/macrophage population in MPD. In view of the known
cooperativity between CSF-1 and other growth factors in regulating
hematopoiesis, the finding of increased serum CSF-1 concentrations and its
association with myeloid metaplasia and bone marrow extension may indicate
a pathophysiologic role for CSF-1 in determining the phenotypic expression
of MPD.
Volume 74,
Issue 4,
pp. 1231-1234,
09/01/1989
Copyright © 1989 by The American Society of Hematology
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