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Dengue virus, a flavivirus, propagates in human bone marrow progenitors and
hematopoietic cell lines [see comments]
S Nakao, CJ Lai and NS Young
Cell Biology Section, National Heart, Lung, and Blood Institute, Bethesda,
MD 20892.
Dengue and other arbovirus diseases are frequently associated with bone
marrow failure. We show that dengue type 4 (DEN4) propagates in colonies
derived from immature human bone marrow progenitors. DEN4 was propagated in
BFU-E-derived colonies and replication was dependent on erythropoietin.
DEN4 was not cytotoxic. In inoculated cultures, diffuse bursts with many
clusters contained large amounts of DEN4 RNA. In contrast to dengue
infection of macrophages, virus propagation in semisolid culture was
sustained and not enhanced by subneutralizing amounts of antibody. DEN4
also was efficiently propagated in human hematopoietic cell lines,
especially those with erythroid properties. In K562 cells, DEN4 infection
persisted for months; greatly slowed cell growth, again without
cytotoxicity; and resulted in cytopathic changes in cell appearance.
Flaviviruses can infect human hematopoietic cells and alter their
proliferative capacity.
Volume 74,
Issue 4,
pp. 1235-1240,
09/01/1989
Copyright © 1989 by The American Society of Hematology
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