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Murine thymocytes proliferate in direct response to interleukin-7
PJ Conlon, PJ Morrissey, RP Nordan, KH Grabstein, KS Prickett, SG Reed, R Goodwin, D Cosman and AE Namen
Immunex Corporation, Seattle, WA 98101.
The ability of interleukin-7 (IL-7) to stimulate murine thymocyte
proliferation was investigated. IL-7, either alone or in concert with
lectin, induced proliferation of adult thymocytes as well as day 13 fetal
and adult CD4-/CD8-thymocytes. The IL-7-induced proliferative response of
unfractionated thymocytes could not be inhibited by antibodies to IL-2, or
IL-4, IL-6, or the IL-2 receptor. In addition, IL-2, IL-4, and IL-6 were
not produced by thymocytes activated with IL- 7, as judged by the absence
of biologically active cytokine in IL-7- stimulated culture supernatants.
IL-7 could act in concert with IL-2 and IL-4 or with IL-4 to enhance the
proliferative response of thymocyte cultures. Thus, IL-7 may cause
proliferation of thymocytes directly, not indirectly, through production of
IL-2, IL-4, or IL-6. IL- 7 may then play a significant role in
differentiation of T lymphocytes.
Volume 74,
Issue 4,
pp. 1368-1373,
09/01/1989
Copyright © 1989 by The American Society of Hematology
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