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Regulation of megakaryocyte development by interleukin-6
J Lotem, Y Shabo and L Sachs
Department of Genetics, Weizmann Institute of Science, Rehovot, Israel.
Megakaryocytes develop in densely seeded normal mouse bone marrow (BM)
cells cultured in agar or in liquid medium. This formation of
megakaryocytes is enhanced by the myeloid differentiation-inducing protein
MGI-2, which we have shown to be interleukin-6 (IL-6). Monoclonal antibody
(MoAb) that specifically neutralizes mouse IL-6 but not human IL-6
inhibited megakaryocyte development in cells cultured either with or
without the addition of mouse IL-6 but did not inhibit megakaryocyte
development induced by human IL-6. This MoAb to mouse IL- 6 that does not
neutralize mouse IL-3 also inhibited mouse IL-3-induced megakaryocyte
development. Antibody to mouse GM-CSF did not inhibit the formation of
megakaryocytes. The results show that the induction of megakaryocyte
development by IL-3 is due to the production of IL-6 in the BM cultures.
The present experiments demonstrate a new property of IL-6 and indicate
that IL-6 is a regulatory protein of normal megakaryocyte development.
Volume 74,
Issue 5,
pp. 1545-1551,
10/01/1989
Copyright © 1989 by The American Society of Hematology
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