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t(3;22)(q27;q11): a novel translocation associated with diffuse non-
Hodgkin's lymphoma [see comments]
K Offit, S Jhanwar, SA Ebrahim, D Filippa, BD Clarkson and RS Chaganti
Laboratory of Cancer Genetics and Cytogenetics, Sloan-Kettering Institute,
New York, NY.
Of 187 specimens of non-Hodgkin's lymphoma and four hyperplastic lymphoid
proliferations with clonal chromosome abnormalities ascertained serially
over a 4 1/2-year period, nine cases with t(3;22)(q27;q11) were identified.
Seven of the lymphomas were diffuse tumors, predominantly large cell type.
The eighth tumor, a follicular small cleaved cell lymphoma, exhibited a
t(3;22) and a t(14;18)(q32;q21). The ninth case was a lymph node from a
human immunodeficiency virus-positive patient which showed atypical
hyperplasia. Overall survival of t(3;22) diffuse lymphoma patients was not
different from that of patients with abnormal karyotypes without t(3;22).
The t(3;22) diffuse tumors studied showed a disproportionate frequency of
lambda light chain on their cell surfaces, a finding similar to that
observed in t(8;22)(q24;q11) Burkitt's lymphomas. Our results indicate that
the t(3;22)(q27;q11) is the third most common recurring translocation in
diffuse non-Hodgkin's lymphoma.
Volume 74,
Issue 6,
pp. 1876-1879,
11/01/1989
Copyright © 1989 by The American Society of Hematology
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