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Expression cloning of cDNA encoding a novel human hematopoietic growth
factor: human homologue of murine T-cell growth factor P40
YC Yang, S Ricciardi, A Ciarletta, J Calvetti, K Kelleher and SC Clark
Genetics Institute, Cambridge, MA.
We used functional expression cloning in mammalian cells to identify a cDNA
clone encoding a hematopoietic growth factor that is mitogenic for the
factor-dependent human megakaryoblastic leukemic cell line, MO7E. Analysis
of the sequence of this cDNA revealed striking similarity to that of a
recently reported novel murine growth factor for helper T- cell clones
designated T-cell growth factor P40. The mRNA for the human P40 protein is
expressed by several different human T-cell lines and by mitogen-stimulated
peripheral blood lymphocytes. The recombinant protein displays substantial
size heterogeneity typical of other glycoprotein cytokines. These
properties plus the observation that this cytokine may well act within both
the lymphoid and myeloid lineages warrant the designation of P40 as
interleukin-9.
Volume 74,
Issue 6,
pp. 1880-1884,
11/01/1989
Copyright © 1989 by The American Society of Hematology
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