|
|
 Previous Article | Table of Contents | Next Article 
A stimulatory effect of recombinant murine interleukin-7 (IL-7) on B- cell
colony formation and an inhibitory effect of IL-1 alpha
T Suda, S Okada, J Suda, Y Miura, M Ito, T Sudo, S Hayashi, S Nishikawa and H Nakauchi
Department of Medicine, Jichi Medical School, Tochigi-ken, Japan.
Using a clonal culture system, we investigated the lymphohematopoietic
effects of recombinant interleukin-7 (IL-7) obtained from conditioned media
of transfected COS 1 cells. IL-7 alone acted on murine bone marrow cells
and supported the formation of B-cell colonies. These colony cells were
positive for B220, and some of them were also found to have either IgM or
Thy-1. B220+, IgM- cells, but not B220- cells sorted from fresh bone marrow
cells were able to form B cell colonies in the presence of IL-7. Thus, IL-7
supported the differentiation of B220+, IgM- cells to B220+, IgM+ cells.
B220+, IgM+ cells did not proliferate in the presence of IL-7. IL-7 did not
affect the myeloid colony formation supported by IL-3, IL-5, IL-6,
granulocyte macrophage colony stimulating factor (GM-CSF), and G-CSF. On
the other hand, lymphocyte colony formation was not affected by IL-2, IL-3,
IL-4, IL-5, IL-6, GM-CSF, or G-CSF. Interestingly, IL-1 alpha inhibited
IL-7- induced B cell colony formation in a dose-dependent manner, while the
same concentration of IL-1 alpha enhanced the myeloid colony formation by
IL-3. This reciprocal effect of IL-1 alpha may act on hematopoietic
progenitor cells without accessory cells. These data show that IL-7 is a B
cell growth factor and that IL-1 alpha may play an important role in
differentiation of myeloid and lymphoid lineages.
Volume 74,
Issue 6,
pp. 1936-1941,
11/01/1989
Copyright © 1989 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
F. B. Aiello, J. R. Keller, K. D. Klarmann, G. Dranoff, R. Mazzucchelli, and S. K. Durum
IL-7 Induces Myelopoiesis and Erythropoiesis
J. Immunol.,
February 1, 2007;
178(3):
1553 - 1563.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Okada, T. Yoshida, Z. Hong, G. Ishii, M. Hatano, M. Kuro-o, Y. Nabeshima, Y.-i. Nabeshima, and T. Tokuhisa
Impairment of B lymphopoiesis in precocious aging (klotho) mice
Int. Immunol.,
June 1, 2000;
12(6):
861 - 871.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. M. Smart and A. R. Venkitaraman
Inhibition of Interleukin 7 Receptor Signaling by Antigen Receptor Assembly
J. Exp. Med.,
February 21, 2000;
191(4):
737 - 742.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Cobaleda, N. Gutierrez-Cianca, J. Perez-Losada, T. Flores, R. Garcia-Sanz, M. Gonzalez, and I. Sanchez-Garcia
A primitive hematopoietic cell is the target for the leukemic transformation in human Philadelphia-positive acute lymphoblastic leukemia
Blood,
February 1, 2000;
95(3):
1007 - 1013.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. I. D. Rossi, H. S. Dutra, M. C. El-Cheikh, A. Bonomo, and R. Borojevic
Extramedullar B lymphopoiesis in liver schistosomal granulomas: presence of the early stages and inhibition of the full B cell differentiation
Int. Immunol.,
April 1, 1999;
11(4):
509 - 518.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. D. Levin, R. M. Koelling, S. L. Friend, D. E. Isaksen, S. F. Ziegler, R. M. Perlmutter, and A. G. Farr
Thymic Stromal Lymphopoietin: A Cytokine That Promotes the Development of IgM+ B Cells In Vitro and Signals Via a Novel Mechanism
J. Immunol.,
January 15, 1999;
162(2):
677 - 683.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Marshall, H. E. Fleming, G. E. Wu, and C. J. Paige
Modulation of the IL-7 Dose-Response Threshold During Pro-B Cell Differentiation Is Dependent on Pre-B Cell Receptor Expression
J. Immunol.,
December 1, 1998;
161(11):
6038 - 6045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Aiba and M. Ogawa
Development of Natural Killer Cells, B Lymphocytes, Macrophages, and Mast Cells From Single Hematopoietic Progenitors in Culture of Murine Fetal Liver Cells
Blood,
November 15, 1997;
90(10):
3923 - 3930.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T Nakano, H Kodama, and T Honjo
Generation of lymphohematopoietic cells from embryonic stem cells in culture
Science,
August 19, 1994;
265(5175):
1098 - 1101.
[Abstract]
[PDF]
|
|
|
|
|
|
|
N M van der Lugt, J Domen, K Linders, M van Roon, E Robanus-Maandag, H te Riele, M van der Valk, J Deschamps, M Sofroniew, and M van Lohuizen
Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.
Genes & Dev.,
April 1, 1994;
8(7):
757 - 769.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Berns, N. van der Lugt, M. Alkema, M. van Lohuizen, J. Domen, D. Acton, J. Allen, P.W. Laird, and J. Jonkers
Mouse Model Systems to Study Multistep Tumorigenesis
Cold Spring Harb Symp Quant Biol,
January 1, 1994;
59(0):
435 - 447.
[Abstract]
[PDF]
|
|
|
|
|
