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Interleukin-6 and interleukin-1 production in acute leukemia with
monocytoid differentiation
CE van der Schoot, P Jansen, M Poorter, MR Wester, AE von dem Borne, LA Aarden and RH van Oers
Central Laboratory, The Netherlands Red Cross Blood Transfusion Service,
Amsterdam.
Several authors have reported the in vitro production of colony-
stimulating factors (CSF) and interleukin-1 (IL-1) by the neoplastic cells
from patients with acute myeloid leukemia (AML). Using a sensitive bioassay
for IL-6, the capacity of the leukemic cells of 30 patients with AML to
produce IL-6 was examined. IL-6 production was found to be specific for
cells from patients with an AML with monocytic differentiation (12 of 15 M4
and M5 patients, 0 of 15 M1 and M2 patients). Moreover, IL-6 production was
paralleled by IL-1 production. The IL-6- and IL-1-producing cells were
mainly found in the more mature monocytic cell fractions, defined as
CD14-positive and CD34-negative adherent cells. By limiting dilution
experiments, it could be excluded that the production of IL-1 or IL-6 was
due to contamination with normal monocytes.
Volume 74,
Issue 6,
pp. 2081-2087,
11/01/1989
Copyright © 1989 by The American Society of Hematology
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