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Gamma/delta lineage relationship within a consecutive series of human
precursor T-cell neoplasms
JP de Villartay, AB Pullman, R Andrade, E Tschachler, O Colamenici, L Neckers, DI Cohen and J Cossman
Laboratory of Chemical Biology, National Institute of Diabetes and
Digestive and Kidney Diseases, Bethesda, MD.
We analyzed the gene rearrangements associated with the newly described
delta T-cell receptor (TCR) gene from a series of 19 consecutive precursor
T-cell (lymphoblastic) neoplasms that represent discrete stages surrounding
the TCR gene rearrangement process. Significantly, the delta TCR gene
showed rearrangement in most (13 of 19) of these T cells, and in addition
it was rearranged in two cells displaying no rearrangement for any other
TCR gene. Our survey showed three types of delta gene rearrangements
associated with cell-surface TCR expression that presumably represent usage
of three V delta genes. This analysis demonstrates (1) a major subclass of
human precursor T-cell neoplasms belonging to the gamma/delta T-cell
receptor-rearranging subtype; (2) a narrow repertoire of human V delta gene
usage; and (3) the utility of delta gene rearrangements as a diagnostic
clonal marker in precursor T lymphoblastic neoplasms.
Volume 74,
Issue 7,
pp. 2508-2518,
11/15/1989
Copyright © 1989 by The American Society of Hematology
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