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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Deeg, H. J. Articles by Storb, R. Search for Related Content PubMed PubMed Citation Articles by Deeg, H. J. Articles by Storb, R. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Prevention of transfusion-induced graft-versus-host disease in dogs by ultraviolet irradiation HJ Deeg, TC Graham, L Gerhard-Miller, FR Appelbaum, F Schuening and R Storb Vincent T. Lombardi Cancer Research Center, Georgetown University, Washington, DC. Ten dogs were given 9.2 Gy of total body irradiation and autologous bone marrow infusion followed by ten daily transfusions of leukocytes for a total of 11.5 to 36.2 (median, 18.8) x 10(8)/kg obtained via leukapheresis from histoincompatible unrelated donors. Four dogs were given unirradiated leukocytes, and all developed graft-versus-host disease (GVHD). In contrast, only two of three dogs given leukocytes irradiated with 20 mJ/cm2 of ultraviolet (UV) light (200 to 300 nm), and none of three dogs given leukocytes irradiated with 1,000 mJ/cm2 developed GVHD. These data indicate that UV irradiation abrogates the alloreactive potential of transfused leukocytes, and suggest that UV irradiation can be used to prevent the development of transfusion- induced GVHD. Volume 74, Issue 7, pp. 2592-2595, 11/15/1989 Copyright © 1989 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Mayumi, K. Matsui, K. Matsuzaki, T. Uchida, K. Shinozaki, and K. Tokunaga Cellular kinetics of posttransfusion graft-versus-host disease after heart operations J. Thorac. Cardiovasc. Surg., July 1, 1994; 108(1): 179 - 182. [Full Text] R. A. Shivdasani, F. G. Haluska, N. L. Dock, J. S. Dover, E. J. Kineke, and K. C. Anderson Graft-versus-Host Disease Associated with Transfusion of Blood from Unrelated HLA-Homozygous Donors N. Engl. J. Med., March 18, 1993; 328(11): 766 - 770. [Full Text]

	Copyright © 1989 by American Society of Hematology         Online ISSN: 1528-0020