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Intact transferrin receptors in human plasma and their relation to
erythropoiesis
HA Huebers, Y Beguin, P Pootrakul, D Einspahr and CA Finch
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
Intact transferrin receptor molecules complexed with transferrin were found
in human plasma. The concentration of receptors was determined by an
enzyme-linked immunosorbent assay that uses polyclonal antibodies. The mean
concentration of 8,279 micrograms/L in 56 normal adults appears to be
unrelated to age or sex. Additional receptor measurements were performed on
plasmas from 260 subjects with erythropoietic disorders. Decreased
concentration of plasma receptors was found in patients with erythroid
hypoplasia and increased numbers in those with erythroid hyperplasia.
Ferrokinetic measurements of erythropoiesis were compared with numbers of
receptors in 148 subjects, and a close correlation was found (r = .86).
Both sets of values, measured in different conditions and expressed in
relation to normal, were consistent with expected values. Receptor values
were unproportionally increased only in conditions of iron deficiency. It
is concluded that plasma receptors have a constant relationship to tissue
receptors, and their number in most instances reflects the rate of
erythropoiesis.
Volume 75,
Issue 1,
pp. 102-107,
01/01/1990
Copyright © 1990 by The American Society of Hematology
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