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TR Ulich, J del Castillo, IK McNiece, SM Yin, B Irwin, K Busser and KZ Guo
Department of Pathology, University of California, Irvine Medical School
92717.
Multi-colony stimulating factor (Multi-CSF, interleukin-3, IL-3) and
granulocyte-CSF (G-CSF) administered concurrently as an intravenous (IV)
injection induce a peripheral neutrophilia that is approximately additive
in comparison with the neutrophilia induced by IL-3 and G-CSF individually.
The bone marrow (BM) at 12 hours is depleted of mature neutrophils and
shows a left-shifted myeloid hyperplasia, consistent with the
neutrophil-releasing and myeloproliferative activities of both IL-3 and
G-CSF individually. The BM at 24 hours shows a replenished reserve of
mature neutrophils and a synergistic left-shifted myeloid hyperplasia as
compared with IL-3 and G-CSF alone. Daily IV injections of IL-3 plus G-CSF
for 1 week also induce an approximately additive daily peripheral
neutrophilia. The BM after a week's administration of IL-3 plus G-CSF shows
a generalized myeloid hyperplasia with a synergistic increase in mature
neutrophils as compared with IL-3 or G- CSF alone. Daily injection of IL-3
plus G-CSF induced a significant decrease in erythroid, lymphoid, and
eosinophilic marrow precursors, possibly owing to a myelophthisic effect of
the myeloid hyperplasia and despite the fact that IL-3 alone induced a
significant erythroid hyperplasia.
This article has been cited by other articles:
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| Copyright © 1990 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
