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Occurrence of cytochrome b558 in B-cell lineage of human lymphocytes
S Kobayashi, S Imajoh-Ohmi, M Nakamura and S Kanegasaki
Institute of Medical Science, University of Tokyo, Minatoku, Japan.
Cytochrome b558, involved in superoxide generation in phagocytes, was found
to be expressed on the cell surface of most normal peripheral B
lymphocytes. The cytochrome was not found on the surface of peripheral T
lymphocytes, natural killer cells, or peripheral lymphocytes derived from
patients with X-linked chronic granulomatous disease. On stimulation, at
least half of peripheral B lymphocytes could generate superoxide anion as
detected by superoxide dismutase-sensitive nitroblue tetrazorium reduction.
Cytochrome b558 was not present on the surface of pre-pre B cells or pre-B
cells, but did appear at the early B-cell stage. It disappeared from the
B-cell surface during terminal differentiation to plasma cells. The
transient expression of the cytochrome in B-cell lineage may indicate that
superoxide generation is important for the function of these cells at
certain stages.
Volume 75,
Issue 2,
pp. 458-461,
01/15/1990
Copyright © 1990 by The American Society of Hematology
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