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Effects of interleukin-4 on the in vitro growth of human lymphoid and
plasma cell neoplasms
CW Taylor, TM Grogan and SE Salmon
Department of Internal Medicine, University of Arizona College of Medicine,
Tucson 85724.
Recombinant human interleukin-4 (rhIL-4) has pleiotropic biologic effects
including stimulation of normal B-cell growth. We investigated the effects
of rhIL-4 on the in vitro growth of 35 fresh human lymphoid and plasma cell
malignancies. Inhibition of growth was seen in 52% and 60% of multiple
myeloma and lymphoma specimens, respectively. Growth was stimulated
relative to control in 8.6% (3 of 35) of the tumors tested.
Immunophenotyping showed that tumors displaying growth stimulation
expressed surface markers associated with a poor clinical prognosis. Our
findings support the clinical evaluation of rhIL-4 as a therapeutic agent
in selected patients with lymphoid and plasma cell neoplasms.
Volume 75,
Issue 5,
pp. 1114-1118,
03/01/1990
Copyright © 1990 by The American Society of Hematology
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