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T lymphocytes from invaded lymph nodes in patients with B-cell-derived
non-Hodgkin's lymphoma: reactivity toward the malignant clone
MC Jacob, MP Piccinni, T Bonnefoix, MF Sotto, P Couderc, JC Bensa and JJ Sotto
Laboratoire de recherche d'immunopathologie tumorale, hopital A. Michallon,
Grenoble, France.
Tumor-infiltrating T lymphocytes (TIL-T) are always present in B-cell-
derived non-Hodgkin's lymphoma (NHL). In this investigation, we explored
the possibility that collaboration might exist between these cells. TIL-T
were isolated from 39 lymph nodes of patients with NHL. In most of the
cases, few of them (less than 10%) possessed surface activation receptors
CD25 or OKT9. In 80% of the cases, they proliferated in response to
recombinant interleukin-2 (rIL-2), but the degree of proliferation was
often low as compared with control populations. The influence of irradiated
autologous malignant cells on the TIL-T proliferation in response to rIL-2
(40 U/mL) was also investigated: in 38% of the cases, this proliferation
was not modified (group O), and in 41% it was higher (group +) and in 21%
it was lower (group -). The mechanism of this immune response (specific or
not) is not elucidated at present. The definition of these groups was
statistically correlated with different parameters of the disease: (1)
percentage of TIL-T was higher in group + (44% +/- 17%) than in group O
(31% +/- 18%) and group - (24% +/- 15%); (2) B-cell proliferation in
centrofollicular lymphomas was more frequently nodular or nodular and
diffuse in group + (83%) and O (55%) than in group - (0%); (3) low- grade
malignancies in the Working Formulation were more frequent in group + (75%)
than in group O (60%) or group - (12%); (4) favorable prognosis evaluated
with the Grenoble cytologic classification was more frequent in group + and
O (87%) than in group - (12%); (5) actuarial survival curves showed a
significantly better prognosis for patients in group +.
Volume 75,
Issue 5,
pp. 1154-1162,
03/01/1990
Copyright © 1990 by The American Society of Hematology
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