Characterization of a new T-lineage glycoprotein expressed in mature T-
cell leukemias and lymphomas
WF Cassano
Division of Pediatric Hematology-Oncology, University of Florida,
Gainesville 32610.
We identified a new human, T-lineage restricted glycoprotein of molecular
weight 120 Kd that is expressed primarily in mature T-cell malignancies.
The antigen, named TCA-1 (T-cell cytoplasmic antigen), is an intracellular
glycoprotein found mainly in the Golgi stacks, although a few cell lines
also display surface membrane TCA-1. Many but not all T-cell neoplasms
express this antigen. The antigen is absent from neoplastic and normal
human tissue outside the T-lymphocyte lineage. TCA-1 was identified by
murine monoclonal antibodies produced after immunization of mice with
T-cell chronic lymphocytic leukemia cells. The glycoprotein is a monomer
containing approximately 4% N- linked carbohydrate with terminal
D-galactose residues. Partial amino acid sequence analysis of TCA-1 shows
homology with an immunoglobulin heavy chain region, which suggests that
TCA-1 may belong to the immunoglobulin supergene family of receptor and
adhesion molecules.
Volume 75,
Issue 7,
pp. 1557-1563,
04/01/1990
Copyright © 1990 by The American Society of Hematology
