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Low expression of lymphocyte function-associated antigen (LFA)-1 and LFA-3
adhesion molecules is a common trait in Burkitt's lymphoma associated with
and not associated with Epstein-Barr virus
M Billaud, F Rousset, A Calender, M Cordier, JP Aubry, V Laisse and GM Lenoir
International Agency for Research on Cancer, Lyon, France.
Lymphocyte function-associated antigens 1 and 3 (LFA-1, LFA-3) and
intercellular adhesion molecule 1 (ICAM-1) are cell surface adhesion
molecules necessary for immune processes requiring intercellular contact.
It was recently proposed that malignant Burkitt's lymphoma cells (BL) may
escape from immunosurveillance through the downregulation of LFA-1
(CD11a/CD18) or LFA-3 (CD58) and ICAM-1 (CD54) molecules. Expression of
these three adhesion antigens was investigated in 19 BL lines. LFA-1 or
LFA-3 expression was found to be absent or low in 8 of 11 Epstein-Barr
virus (EBV) genome positive BL, but strongly expressed on all nonmalignant
EBV genome positive lymphoblastoid cell lines (LCL). Negative or weak
expression of LFA-1 and LFA-3 was also observed in 7 of 8 EBV genome
negative BL. ICAM-1 was found to be expressed on the cell surface of the
majority of BL lines. BL lines growing as individual cells did not express
LFA-1, whereas clump- forming BL lines expressed this marker involved in
B-cell homotypic aggregation. Expression of LFA-1 and LFA-3 was induced on
in vitro infection of EBV-negative BL cells with the immortalizing EBV
strain B95-8, and weakly with the nonimmortalizing EBV strain P3HR1. EBNA2
and LMP, two EBV encoded proteins expressed in LCL and in BL infected with
B95-8 (BL/B95-8), are not expressed in P3HR1 infected BL cells (BL/P3HR1).
Stable expression of EBNA2 after gene transfer in a BL/P3HR1 cell line did
not restore the level of LFA-1 and LFA-3 found on BL/B95-8 cells. In
EBV-positive BL cells expressing LFA-1 and LFA-3, LMP was found
coexpressed, supporting the recent finding of the role of LMP in B-cell
adhesion receptor activation. Consequently, diminished LFA-1 and LFA-3
expression appears to be a common characteristic of numerous EBV-positive
BL as well as EBV-negative BL. These findings are discussed in the
framework of BL pathogenesis.
Volume 75,
Issue 9,
pp. 1827-1833,
05/01/1990
Copyright © 1990 by The American Society of Hematology
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